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Negida Research Academy/C5: Systematic Review and Meta-analysis [Arabic]
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C5: Systematic Review and Meta-analysis [Arabic]


Learn the gold-standard methods to conduct systematic reviews and meta-analysis of interventional studies.
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Registration Methods

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If you use PayPal, click on the "Buy Now" button and continue the process through PayPal. After checkout, you will get immediate enrollment in the course. 
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Other Methods?

If you do not use PayPal, fill out this registration form: https://forms.gle/wCoHoJDGS4XorEMM8 and follow the instructions of the course coordinator. He will contact you by email and you will be enrolled manually in the course.
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The following items are covered in the course

โ–ช Why do we need systematic reviews?
โ–ช Types of Systematic Reviews
โ–ช Steps of Systematic Reviews
โ–ช Review question
โ–ช Developing the review criteria
โ–ช How to search the literature
โ–ช Methods of screening
โ–ช Tips for data extraction
โ–ช Quality assessment of RCTs using Cochrane ROB tool
โ–ช PRISMA flow diagram โ€ 
โ–ช Risk of bias figure and risk of bias summary โ€ 
โ–ช Introduction to the Meta-analysis
โ–ช Interpretation of Forest plot
โ–ช Pooling continuous and dichotomous data โ€ 
โ–ช Interpretation of Funnel plot for Assessment of Publication bias
โ–ช Subgroup analysis and Sensitivity analysis โ€ 
โ–ช PRISMA checklist
โ–ช Meta-analysis workshop (3 case scenarios)
โ–ช Estimation of missing data in meta-analysis
โ–ช Meta-regression analysis: concept, procedures, and interpretation โ€ก
โ–ช Cumulative meta-analysis โ€ก
โ–ช Leave one out meta-analysis โ€ก
โ–ช IPD meta-analysis, NMA network meta-analysis (define & example only)

Live Online Lectures

  • The full course is explained by Dr. Negida through 4 live lectures on ZOOM, twice per year, usually in Winter & Summer. 
  • Follow the course contents page - "Live Lectures" section for announcements and links to the sessions of this course.
  • You can join any of the live lectures if you want + PLUS + you can study from the recorded video lectures of the old versions of the course (see below).

Recorded Video Lectures

By joining the course, you are also gaining access to the old versions of the course. 

  • The full course as recorded video lectures of NCRT - Summer 2019 [12 hours]

  • The full course as recorded video lectures of NCRT - Summer 2020 [12 hours]

Course Contents

๐Ÿ”ฅ NEW ๐Ÿ”ฅ Summer 2022

Zoom Link for the Live Lectures
Recorded Video, Lecture 1 (25 August)
Recorded Video, Lecture 2 (26 August)
Recorded Video, Lecture 3 (28 August)
Recorded Video, Lecture 4 (29 August)

Archived ๐Ÿ•ต๐Ÿปโ€โ™‚๏ธ Winter 2022

Zoom Link for the Live Lectures
Recorded Video, Lecture 1 (3 March)
Recorded Video Lecture 2 (4 March 2022)
Recorded Video, Lecture 3 (5 February)
Recorded Video, Lecture 4 (6 March)

Archived ๐Ÿ•ต๐Ÿปโ€โ™‚๏ธ Summer 2021

Zoom registration link
Recorded Lecture 1
Recorded Lecture 2
Recorded Lecture 3
Recorded Lecture 4

Archived ๐Ÿ•ต๏ธโ€โ™‚๏ธ Winter 2021

Questions & Group Discussions
Lecture 1.mp4
Q&A before Lecture 2.mp4
Lecture 2.mp4
Q&A before Lecture 3.mp4
Lecture 3.mp4
Lecture 4.mp4

Examples for Systematic Review and Meta-analysis

5 Examples for Systematic Reviews and Meta-analysis published by Dr. Negida (Droxidopa, Coenzyme Q10, HARP, Sunitinib, and DBS Neuropsy).

Other examples are provided here for guidance purposes& were conducted by other researchers (not related to Dr. Negida and his team).
Droxidopa.pdf
Coenzyme Q10.pdf
DBS Neuropsy.pdf
Sunitinib.pdf
HARP.pdf
Neurosurgery.pdf
Interventional Cardiology.pdf
Obstetrics.pdf
Oncology.pdf
Surgery.pdf
Dentistry.pdf
Interventional Cardiology Radiology.pdf
Interventional Cardiology 2.pdf
Radiology.pdf

Lecture 1

  • Introduction to Systematic Review
  • Systematic Review vs. Literature Review
  • Importance of Systematic Reviews
  • Types of Systematic Reviews
  • Steps of Systematic Reviews

  • ** Step 1 ** Research Question
  • ** Step 2 ** Defining the Eligibility Criteria
  • ** Step 3 ** Literature Search
  • ** Step 4 ** Screening of Records
Lecture notes written by Dr. Negida [theoretical].pdf
Guide for searching databases & Endnote with Screenshots.pdf
1. Introduction to Systematic review.pdf
2. Introduction to Meta-analysis.pdf
3. Review Question and Eligibility Criteria.pdf
4. Literature Search and Screening.pdf
PROSPERO; International prospective register of systematic reviews

Homework/Workshop 1: Defining the Research Question & Eligibility Criteria

Assignment 1
Assignement 2
Understanding the Risk of Bias in Randomized Controlled Trials

Lecture 2

  • Quality Assessment of RCTs
  • Baseline Characteristics Table
  • Manuscript Writing According to the PRISMA template
  • Introduction to Meta-analysis
  • Softwares of Meta-analysis
  • Effect Estimates of Meta-analysis
5. Quality Assessment of Randomized Controlled Trials.pdf
Note: How to Judge the overall Risk of Bias
6. Baseline Characteristics Table.pdf
7. Meta-analysis Softwares.pdf
8. Effect Estimates.pdf
9. Before undertaking the analysis.pdf
Download RevMan Software
When to use the SMD not the MD as the effect estimate
When to use the Odds Ratio (OR) instead of the Risk Ratio (RR)

Homework/Workshop 2: Assessing the Quality of RCTs according to the ROB

Assignment 3
RCT for Quality Assessment - Anderson 2005.pdf
RCT for Quality Assessment - Odekerken2013.pdf
RCT for Quality Assessment - Follett2010.pdf
RCT for Quality Assessment - Rothlind2007.pdf
Assignment 4

Lecture 3

9. Before undertaking the analysis.pdf
10. Fixed versus Random effect model.pdf
11. Forest Plot Interpretation.pdf
Interpretation of forest plot (if favored X)
Interpretation of forest plot (if did not favor any drug)
Interpretation of sensitivity analysis
12. Heterogenity.pdf

Homework/Workshop 3: Pooling Data in the Meta-analysis Model using RevMan

Assignment 3
Assignment 4
Assignment 5
Activity 1 - Droxidopa OHQ.xlsx
Activity 2 - AFQ UPDRS.xlsx
Activity 3 - SOF & VEL for HCV.xlsx

Lecture 4

Download Open Meta[analyst] Software
How to Handle Heterogeneity in Meta-analysis
Calculate mean and SD from Median IQR.pdf

Homework/Workshop 4: Assessing Heterogeneity and Conducting the Subgroup Analysis & Sensitivity Analysis

Assignment 6: Assess & interpret the Heterogeneity
Assignment 7: Sensitivity Analysis
Activity 1 - Droxidopa OHQ.xlsx
Activity 3 - SOF & VEL for HCV.xlsx
Activity 2 - AFQ UPDRS.xlsx
Systematic Review and Meta-analysis QUIZ

Zoom Lectures' Videos 2019, 2020, and 2021

Zoom lectures links are posted to this section, which includes the following:
  • Recorded Lectures of previous seasons
  • Live Lectures of the upcoming seasonย 
4 video lectures - Full course - Summer 2019

Course Supplements + Advanced resources that are not included in the course

Cochrane Handbook of Systematic Reviews and Meta-analysis of Interventions
History of meta-analysis.pdf
Multiplicity and data extraction errors.pdf
Epidemiology and reporting.pdf
PRISMA Clist.pdf
Outcome reporting bias.pdf
Funnel plot.pdf
PRISMA E&E.pdf
Publication bias.pdf
Randomisation and concealed allocation.pdf
Searching beyond Medline.pdf
Sample size and data analyses.pdf
Attrition bias.pdf
Blinding.pdf
Constraints on publication rights.pdf
Study design biases.pdf
Cohrane Handbook.pdf

[NOT INCLUDED IN THE COURSE] Stata Do-files for Meta-analysis

Templates of Do-files including all Meta-analysis commands on Stata software.

These files are used only for STATA software workshops given by Dr. Negida.

You do not need to download or use these files unless you are asked by Dr. Negida to do that.
generate SD pooled.do
1.dta
2.dta
Metaregression.do
OHQ.do
Steprtokinase confunnel.do
steprokinase mortality metan.do
Steprtokinase egger's.do
Steprtokinase Metatrim.do
steprtokinase mortality meta .do
subgroup analysis SMD.do